Phomopsidin

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August undefined, 2024

WebIsolation and characterization of bioactive metabolites from marine-derived filamentous fungi collected from tropical and sub-tropical coral reefs. Two new compounds, … WebOn the other hand, phomopsidin was not detected in other related, but apparently rare species like H. texense, H. crocopeplum and H. carneum. Only the two latter species, however, were represented in our study by cultures that were isolated from stromata growing on Fraxinus wood. In addition, our results need to be further validated because …

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WebAbstract The absolute configuration of phomopsidin, a marine-derived fungal metabolite from Phomopsis sp. isolated at Pohnpei, was determined by the exciton chirality method as 6S, 7S, 8S, 11S, 12R, and 15R. The biosynthetic study using 13C-labeled precursors revealed the origin of all carbon atoms in phomopsidin, which was built by nine acetates and three … WebPhomopsidin, a New Inhibitor of Microtubule Assembly Produced by Phomopsis sp. Isolated from Coral Reef in Pohnpei MICHIO NAMIKOSHI , HISAYOSHI KOBAYASHI , TAKESHI … how kitchen nightmares works

Phomopsidin, a New Inhibitor of Microtubule Assembly Produced …

WebAbstract. (Equation presented) The first total synthesis of (+)-phomopsidin has been achieved via a diastereoselective transannular Diels-Alder (TADA) reaction. Key steps in … WebExcept where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ?) Phosphamidon is an organophosphate insecticide first reported in … WebPhomopsidin, a New Inhibitor of Microtubule Assembly Produced by Phomopsis sp. Isolated from Coral Reef in Pohnpei. The Journal of Antibiotics, 1997. Tsuyoshi Hosoya. Download Download PDF. Full PDF Package Download Full PDF Package. This Paper. A … how kisses are made

Absolute Structure, Biosynthesis, and anti-Microtubule …

WebJan 24, 2009 · In 1997, (+)-phomopsidin ( Fig. 1) was isolated from a marine-derived fungus, Phomopsis sp. strain TUF 95F47, that was collected in Pohnpei. 1 (+)-Phomopsidin was … WebJan 16, 2004 · The first total synthesis of (+)-phomopsidin has been achieved via a diastereoselective transannular Diels−Alder (TADA) reaction. Key steps in the synthesis … how kiss womanWebJan 20, 2003 · Phomopsidin and its (16Z)-isomer (MK8383) showed anti-microtubule activity at IC 50 of 5.7 and 8.0 μM, respectively, while the Me ester and other compounds were not active at 100 μM. The absolute configuration of phomopsidin ( 1 ) was … how kites are made

"WebMay 20, 2003 · Phomopsidin (33) is a polyketide that interacts with microtubules [59]. This compound that was embedded in a small molecular family was annotated and originated … " - Phomopsidin

Phomopsidin

WebFeb 19, 2004 · [reaction: see text] The first total synthesis of (+)-phomopsidin has been achieved via a diastereoselective transannular Diels-Alder (TADA) reaction. Key steps in the synthesis include diastereoselective ynone reduction with (-)-alpha-pinene and 9-BBN, macrocyclization by E-selective intramolecular … WebPhomopsin A C36H45ClN6O12 CID 6438581 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...

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WebThe absolute configuration of phomopsidin, a marine-derived fungal metabolite from Phomopsis sp. isolated at Pohnpei, was determined by the exciton chirality method as 6S, … WebPhomopsidin C21H30O3 CID 10381991 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …

WebDec 5, 2012 · The Journal of Antibiotics - Identification of a new phomoxanthone antibiotic from Phomopsis longicolla and its antimicrobial correlation with other metabolites during … WebJun 11, 2024 · Perï¬ uoroalkanes Graham Sandford Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK Tetrahedron 59 (2003) 437 Absolute structure, biosynthesis, and anti-microtubule activity of phomopsidin, isolated from a marine-derived fungus Phomopsis sp. Hisayoshi Kobayashi,a,* Shiori Meguro,b Takeshi Yoshimotob and …

WebDec 5, 2012 · The Journal of Antibiotics - Identification of a new phomoxanthone antibiotic from Phomopsis longicolla and its antimicrobial correlation with other metabolites during fermentation WebThis manuscript describes an alternative synthetic approach for (+)-phomopsidin, which shows strong inhibitory activity against the assembly of microtubule proteins. We observed that the TADA reaction of the macrolactone 5 with the reversed C11 configuration provided the desired cycloadduct 6 in 86% yield with excellent stereoselectivity (dr=16:1).

WebThey appear to be species-specific marker molecules in H. carneum from different geographic regions, but do not constitute major metabolites of more than 100 species of …

WebNov 21, 2024 · Metabolite profiling of this crude extract tentatively revealed the presence of the following secondary metabolites: 1,8-dihydroxynaphthalene (1), anserinone B (2), phelligridin B (3), metacytofilin (4), phomopsidin (5) and vermixocin A (6). Compounds 2 and 3 have been shown to be cytotoxic in literature. how kitchen timer worksWebApr 24, 2024 · During a survey of xylarialean fungi in Northern Iran, several specimens that showed affinities to the Hypoxylon rubiginosum complex were collected and cultured. A comparison of their morphological characters, combined with a chemotaxonomic study based on high performance liquid chromatography, coupled with diode array detection … how kites workWebJun 1, 2024 · Phomopsidin, a known inhibitor of beta-tubulin that targets the eukaryotic cytoskeleton, inhibited the pathogen, but also showed mild cytotoxic effects. how kites fly explanation textWebThe Journal of Antibiotics, 1997 Volume 50 Issue 10 Pages 890-892 how kittens are bornWebJan 1, 2004 · A Chemoenzymatic Synthesis of the cisDecalin Core Associated with the Novel AntiMitotic Agent Phomopsidin: Some Observations Concerning a High-Pressure-Promoted Diels–Alder Cycloaddition Reaction... how kitty genovese destroyed childhoodWebJan 24, 2009 · This manuscript describes an alternative synthetic approach for (+)-phomopsidin, which shows strong inhibitory activity against the assembly of microtubule proteins. We observed that the TADA... how kittens can a cat haveWebApr 24, 2024 · found to produce the anti-fungal beta-tubulin inhibitor phomopsidin in dual cul-ture with virulent strains of the pathogen. is compound was rst reported from a . how kiwi saved the forest